Human Papillomavirus (HPV) is responsible for a variety of skin and mucosa disorders. To date, over 100 different HPV genotypes have been described, of which more than 40 infect the anogenital tract.
The anogenital HPVs are generally divided into two categories: those with a low oncogenic potential risk (Low-Risk Group) and those with a medium-high oncogenic potential risk (High-Risk Group).
The high-risk HPVs are generally associated with high-grade precancerous lesions and invasive cancer, while low-risk HPVs are frequently found in asymptomatic or benign conditions such as genital warts.
The Papilloma Strip High Risk / Low Risk test allows, in combination, an efficient analysis of 37 genotypes of Human Papilloma Virus. Specific primers are used for regions E6 and E7 of each of the 37 HPV genotypes of HPV detectable with the kit to perform a multiplex PCR. Since the expression of the E6 and E7 genes is directly associated with carcinogenesis, the detection of these targets can provide significant biological and pathological information. Studies have shown that in samples of cervical cancer positive for the E6 region, the L1 gene could not be detected in 30% of cases, due to a gene deletion process that occurred when high-risk HPV DNA was integrated with that of epithelial cells
PapillomaStrip test is a test based on the reverse blot technique that allows qualitative detection in DNA samples from cervico-uterine smears or biopsies, of 37 human Papillomavirus subtypes:
– Medium-high risk: 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 69, 73 and 82 (MM4 e IS39).
– Low risk: 6, 11, 40, 42, 43, 44, 54, 61, 62, 67, 70, 71, 72, 74, 81, 83, 84 y 91.
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